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Article: Dihexa

Dihexa - HealthBrew Clinic
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Dihexa, an emerging synthetic peptide, is capturing the attention of scientists and biohackers alike. Though still in the early stages of research, this compound holds the promise of substantial benefits in the realms of cognitive function and neurodegenerative diseases like Alzheimer's and Parkinson's. This article provides an in-depth look at what Dihexa is, its proposed mechanism of action, its potential in various therapeutic applications, its safety profile, and dosing considerations.

What is Dihexa?

Born out of research at Washington State University, Dihexa is engineered to facilitate neural repair and communication. As a derivative of angiotensin IV, it acts as a hepatocyte growth factor (HGF) mimetic. It aims to stimulate synaptic connectivity and restore brain damage, making it a fascinating candidate for treating cognitive impairments and degenerative conditions.

Mechanism of Action: A Deeper Dive

Dihexa's unique mechanism of action focuses on repairing and augmenting synaptic connections, rather than just managing symptoms. But how does it accomplish this?

Role of HGF and Upregulation of BDNF

HGF, or hepatocyte growth factor, is a protein crucial for cell growth, survival, and regeneration in various tissues. In the brain, HGF interacts with c-Met receptors on neurons, initiating a cascade of neuroprotective and neuroplastic events. One of the key outcomes of this interaction is the upregulation of Brain-Derived Neurotrophic Factor (BDNF).

BDNF plays a pivotal role in the survival, differentiation, and growth of neurons. It is vital for synaptic plasticity, a cellular mechanism underpinning learning and memory. Upregulation of BDNF essentially makes the brain more adaptable and capable of forming new neural connections, thereby potentially reversing or preventing cognitive decline.

Other Roles of HGF

While HGF is extensively studied for its effects on neural tissue, it originally got its name for its role in liver regeneration. Yes, HGF can improve liver function by stimulating liver cell growth, promoting tissue repair, and offering some degree of protection against liver injuries. However, it's crucial to note that Dihexa's primary application remains centered on brain health rather than liver function.

Therapeutic Applications

Alzheimer’s Disease

Dihexa's reparative capabilities are especially intriguing for Alzheimer's research. For instance, a 2012 study led by Dr. Joseph Harding reported that the peptide reversed cognitive deficits in animal models with Alzheimer's-like symptoms. Dihexa has also shown a capacity to cross the blood-brain barrier, which presents a unique advantage.

Parkinson’s Disease

In collaboration with the Michael J. Fox Foundation, Dr. Joseph Harding is researching Dihexa's application in Parkinson's disease. Preliminary findings in pre-clinical models suggest a restoration of lost motor functions, although it's not clear whether this is due to new nerve cell generation or the repair of existing ones.

Safety Profile and Limitations

The safety profile of Dihexa is not fully understood due to the lack of extensive clinical trials. Short-duration studies so far have not indicated toxicity, but the long-term effects are unknown. Anecdotal evidence from users has indicated side effects like attention deficit and water retention. However, these are not medically confirmed.

Dosing and Administration

There is currently no standardized dosing for Dihexa. Recommendations based on anecdotal evidence range from 8 mg to 45 mg daily. Transdermal application is popular, although various methods like intravenous injections have been experimented with in animal studies. Individuals should proceed cautiously and consult healthcare providers for personalized advice.


Dihexa stands as an exciting yet not fully understood compound in the sphere of cognitive enhancement and neurodegenerative disease treatment. Its unique mechanism, involving the upregulation of BDNF through HGF interaction, sets it apart from existing treatments. However, until further research is conducted, its full range of effects and safety profile remain inconclusive.

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