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Article: Dutasteride

Dutasteride - HealthBrew Clinic

Dutasteride

Dutasteride was first approved by the FDA in 2001 for the treatment of benign prostatic hyperplasia (BPH). Over the years, its off-label use for hair loss and hair growth has gained attention.

Mechanism of Action

Dutasteride inhibits the 5-alpha-reductase enzyme, which converts testosterone to dihydrotestosterone (DHT). This action helps reduce the size of an enlarged prostate. Additionally, inhibiting DHT can also aid in hair growth and prevent hair loss.

FDA-Approved Uses

  • Benign Prostatic Hyperplasia

Off-Label Uses

  • Hair loss and hair growth: Various studies have shown that dutasteride can be effective in promoting hair growth.

Clinical Evidence

Studies indicate that about 2% to 3% of men taking dutasteride experience decreased libido, and around 1% to 2% encounter erectile dysfunction. These rates are relatively low and often reversible. Reference

Side Effects

  • Decreased libido (2-3% of users)
  • Erectile dysfunction (1-2% of users)
  • Other minor side effects include dizziness and gastrointestinal issues.

Drug Interactions

  • Blood thinners like warfarin
  • Other 5-alpha-reductase inhibitors
  • Some antifungals and antibiotics ( Dutasteride is metabolized in the liver via this enzyme system. Some antifungal agents like ketoconazole, itraconazole, and voriconazole are known to inhibit CYP3A4, which could increase the levels of dutasteride in the blood, potentially heightening its effects and side effects)

Contraindications

  • Pregnancy
  • Allergy to dutasteride or similar drugs

Warnings and Precautions

Men taking dutasteride should be cautious about donating blood until at least 6 months after their last dose to prevent pregnant women from receiving dutasteride through blood transfusion.

References

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