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Article: PTD-DMB

PTD-DMB - HealthBrew Clinic


Hair loss affects millions worldwide, and the quest for effective treatments is ongoing. One exciting new development is a peptide known as PTD-DBM, which originated from research conducted at Yonsei University in South Korea led by Dr. Kang-Yell Choi. Backed by CK Biotechnology Inc, this innovative treatment is on track for human trials and commercial development.


The discovery of PTD-DBM as a potential hair loss treatment made headlines across major publications like Korea Times and South China Morning Post. Dr. Choi's research was first published in the Journal of Investigative Dermatology and covered in the U.S. National Library of Medicine. Further updates were shared on by Hasson & Wong, a top-ranked hair clinic.

Mechanism of Action

The science behind PTD-DBM rests on the WNT signaling pathways within cells. These pathways play a critical role in follicle development and hair regeneration. The compound targets a protein called CXXC5 that disrupts WNT signaling and contributes to hair loss. PTD-DBM acts as a CXXC5 inhibitor, promoting hair growth by activating these crucial pathways.

The Science of the Name

For those curious, PTD-DBM stands for "Protein Transduction Domain - Dishevelled Binding Motif". This name is quite a mouthful, but each part of it describes the compound's role. PTD helps with protein transduction within the cell, and DBM binds to the protein Dishevelled, thereby affecting the WNT pathway.

Off-label Uses and Benefits

Apart from its potential in treating hair loss, PTD-DBM's CXXC5 inhibiting properties may also find applications in wound-induced hair neogenesis, as indicated in the same Journal of Investigative Dermatology article.

Risks and Side Effects

As with any new treatment, the long-term safety profile of PTD-DBM is not yet fully understood. Initial studies suggest minimal side effects, but caution is advised for individuals with skin conditions or allergies.

Future Prospects

The future looks promising for PTD-DBM with planned human trials by CK Biotechnology Inc. This work continues to build on Dr. Choi's groundbreaking research, potentially opening a new chapter in hair regrowth treatment.

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