Not FDA approved for Longevity (yet)
Weekly Rapamycin (Sirolimus) for Longevity
Rapamycin is an mTOR (mechanistic Target of Rapamycin) inhibitor that influences pathways associated with cellular growth, proliferation, and metabolism. Inhibiting mTOR helps cells manage resources more efficiently, directing energy toward maintenance and repair rather than rapid growth, which in turn may slow aspects of the aging process. This slower cellular "wear and tear" is associated with longer cellular function and potentially contributes to longevity.
Photo significance: Ikaria, Greece is a special place where a third of the population lives past 90 years old and the average lifespan is more than 10 years higher than the rest of Europe and the US.
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Longevity Protocol Lvl I: Cell Senescence
Rapamycin Longevity Protocol
Only $155 per month!
This protocol targets the aging process at the cellular level, helping reduce inflammation, support autophagy, and promote healthier aging by modulating the mTOR pathway. By incorporating Rapamycin, the protocol addresses multiple hallmarks of aging to help improve overall longevity potential.
The PEARL (Participatory Evaluation of Aging with Rapamycin for Longevity) study, currently being conducted with researchers at UCLA, is a multi-year human trial investigating whether once-weekly low-dose rapamycin can slow age-related decline in healthy adults. Interim analyses from the study’s ongoing 4–5 year observation suggest that participants taking a weekly dose of approximately 5–10 mg of rapamycin have shown improvements in certain biomarkers linked to aging, including reductions in inflammatory markers such as C-reactive protein (CRP) and favorable shifts in epigenetic age (as measured by DNA methylation clocks). These early results are promising, indicating that rapamycin may help modulate fundamental aging processes and improve overall healthspan. Ongoing assessments are evaluating changes in glucose metabolism, lipid profiles, and immune cell populations, though the most notable improvements reported to date are in inflammation and epigenetic aging indicators.
Move to the frontline of longevity science
How Does It Work?
The Longevity Protocol uses Rapamycin to target cellular pathways, promoting anti-aging benefits through mTOR inhibition.
Rapamycin is an mTOR inhibitor that helps to slow down the aging process by regulating cell growth and metabolism, reducing inflammation, and promoting autophagy.
Supports healthy aging, promotes cellular health, and reduces inflammation to improve the body's longevity potential. Research suggests its impact on hallmarks of aging, including genomic instability, mitochondrial dysfunction, and cellular senescence.
While lower doses used for longevity are generally well-tolerated, risks include immunosuppression, mouth ulcers, elevated cholesterol, impaired wound healing, and possible glucose intolerance. For detailed safety information, refer to the FDA Drug Safety Communication (July 2021). Thus far, we only had one member develop a single mouth ulcer with the 6 mg weekly dose and fortunately it did not recur in subsequent weeks.
Most of the studies were based on animal models and the few human studies we have have used 6mg weekly dose with minimal side effects.
Like controlling blood sugar, controlling inflammation can have profound benefits!
Benefits
- ✅Reduces inflammation and cellular senescence
- ✅Promotes autophagy for healthier aging
- ✅Supports cardiovascular and metabolic health
- ✅Helps maintain cognitive function
- ✅Impacts multiple hallmarks of aging including genomic stability and proteostasis
Side Effects
Potential side effects include immunosuppression, increased cholesterol, mouth ulcers, and impaired wound healing. The severity and occurrence are dose-dependent and should be monitored by healthcare professionals. Thus far, we only had one member develop a single mouth ulcer with the 6 mg weekly dose and fortunately it did not recur in subsequent weeks.
Rapamycin should not be used during pregnancy as it may harm the unborn baby. Effective contraception is advised during treatment.
Unlike other companies...
We don't bait with "starting at" prices.
Wellness Done Right.
Only Legitscript certified & NABP accredited pharmacies are part of the HealthBrew Network.
Prescription Strength Protocols. No subscriptions or hidden fees!
The HealthBrew Customer Experience.
Step 1: Purchase Membership Package.
Step 2: Register New Patient Profile.
Step 3: Receive Protocol Meds by Mail. Refill as Needed.
Refill as needed. Video consultation is optional. Chat support is 24/7.
Our perspective on aging
How We Think of Aging
Aging doesn’t have to feel like an inevitable decline. Think of it this way: over time, our cells get bogged down with unnecessary burdens that keep them from doing what they’re naturally great at—repairing and renewing themselves, or what we like to call “regeneration.” This buildup leads to “old” cells, kind of like an old car sitting in your garage, leaking oil and puffing out black smoke. The good news? We can do something about it.
At HealthBrew, we focus on building simple, effective protocols to tackle three main culprits behind aging:
- Sugar spikes (glycation),
- Cortisol spikes (hormonal stress), and
- Inflammation spikes (inflammaging).
On top of that, we also offer some fun aesthetic peptides to help you feel your best. But when it comes to slowing aging, those three areas are where we get to work.
We’re excited about hosting AMA (“Ask Me Anything”) live streams and webinars down the road so we can connect, share stories, and dig deeper into this journey together. For now, just know that it all starts with your daily habits. Those are your #1 tool to fight aging. HealthBrew’s protocols are here to be your #2—helping you take it to the next level.
If you’ve been with us for a year or more, it might be a great time to check in and see how you’re doing with our discounted DNA test to measure your speed of aging. Because slowing down the clock? That’s the win we’re all after.
Now, a quick heads-up: some of what we offer is considered off-label. That’s just because clinical trials on humans take a long time, but there’s a ton of solid animal research out there, and it’s pointing us in the right direction. We’re here to make the science practical, approachable, and—most importantly—useful to you.
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The information provided on this website is for informational purposes only and does not constitute medical advice. Please consult your healthcare provider before starting any treatment. All protocols are experimental and involve off-label use of medications. This protocol has not been FDA approved for the specified use. For more information, visit www.fda.gov/drugs.